Pharmaceutical Twin Screw Extruders





Pharmaceutical 12mm Twin Screw Extruder

PTSE® 12/36
Pharmaceutical
12mm Twin Screw Extruder


• Compact design (low space requirement)
• Suitable for early development and preparation of samples for clinical studies
• Clamshell barrel allowing troubleshooting and easy cleaning
• Removable liner (for fast cleaning or sterilization)
• Small batch size (suitable for expensive actives)
• Multiple heating and cooling zones
• Heatable die head
• Fast and accurate temperature regulation from both upper and lower sides of barrel
• Segmented screws
• High maximal torque suitable for the processing of pharmaceutical materials
• Separate special cooling for the feeding zone
• Several top-openings
• Side-opening for side feeding
• Process length can be shortened

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Pharmaceutical 20mm Twin Screw Extruder

PTSE® 20/40
Pharmaceutical
20mm Twin-Screw Extruder


• Compact design (low space requirement)
• Suitable for pilot scale
• Clamshell system allowing trouble shooting and easy cleaning
• Removable liner (for fast cleaning or sterilization)
• Segmented screws
• High maximal torque (suitable for the processing of pharmaceutical substances)
• Separate special cooling for the feeding zone
• Multiple heating and cooling zones
• Heatable die head
• Fast and accurate temperature regulation from both upper and lower part of the barrel
• Several top openings
• Side-openings for side feeding
• Process length can be shortened

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PHARMACUETICAL
SALES CONTACTS:

The Americas:

Paul Nardone
Phone: 201.343.8425

Fax: 201.343.0608
pnardone@cwbrabender.com

 

 

The rest of the World:

Jane Schwarz
Phone: +49 - 203 - 7788 - 119
Jane.Schwarz@brabender.com

The hot-melt extrusion solution

Challenge

HME Solution

• Low bioavailability due to poor API solubility • Rapid and cost-effective method for solubility enhancement of poorly soluble APIs (continuous, no drying step is needed
  
• Stability issues (moisture sensitive API) • Dry process suitable for moisture sensitive drugs
  
• Unpleasant taste of API • Taste masking of poorly tasting APIs through HME
  
• Non-robust prolonged release properties • Easy, reliable way to achieve prolonged drug release
• Reduced risk of dose dumping compared to coated monolithic systems
• No solvents (safety, cost and time-saving as no subsequent drying is needed)
  
• Formulation of API as films • HME as a rapid and reliable method for preparation of films (strips or patches)

Benefits of extrusion in the pharmaceutical industry

• Continuous process (time and cost saving, better controllability) against batch processes
 
• Well established technology (wide spectrum of excipients commercially available and high level of expertise is already established)
 
• Highly reproducible process (batch uniformity and conformity)
 
• Flexible process (monolithic and multiparticulate dosage forms can be obtained)
 
• Easy, time and cost saving way to modify drug release properties (solubility enhancement or release prolongation)

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Pharmaceutical Exhibitions / Events

AAPS 2014 Annual
Meeting & Expo

 San Diego, CA Nov. 2 - 6, 2014

All dates

All other Contacts

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Software Downloads

All software downloads must be purchased prior to clicking below by contacting the C.W. Brabender® parts dept.

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